https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47161 Cissampelos sympodialis Eichler, Menispermaceae, is a native Brazilian plant used in folk medicine to treat asthma and has central nervous system effects. Anxiety is a prevalent comorbidity of asthma raising the potential for the development of monotherapy for both diseases. We evaluated the effectiveness of the alcoholic fraction of leaves of C. sympodialis and its isolated alkaloid warifteine in treating anxiety- and asthma-like symptoms in mice with ovalbumin-induced allergic airway disease. Ovalbumin-sensitized BALB/c mice were treated with the plant extract or alkaloid orally, or with diazepam or dexamethasone controls, before ovalbumin challenge. Plant extract and warifteine treatments ameliorated anxiety-like symptoms and improved respiratory rate similar to diazepam in conscious allergic mice but did not ameliorate airway hyper-responsiveness. Plant extract and warifteine also reduced leukocyte migration into the airways and Th2 cytokine levels in bronchoalveolar lavage and lung tissue similar to dexamethasone. Our data indicate that C. sympodialis and its isolated alkaloid warifteine represent potential monotherapies to treat anxiety and asthma symptoms.]]> Wed 14 Dec 2022 15:41:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15023 Wed 11 Apr 2018 16:31:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20247 Wed 11 Apr 2018 12:24:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16746 Wed 11 Apr 2018 09:23:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16906 A agonist muscimol or saline into the amygdala bilaterally and were subjected to a respiratory recording using whole body plethysmography. Presentation of acoustic stimuli (500-ms white noise, 40–90 dB) caused transient responses in respiratory rate that were proportional to the stimulus intensity, ranging from +13 ± 9 cpm to +276 ± 67 cpm for 40- and 90-dB stimuli, respectively. Inhibition of the amygdala significantly suppressed respiratory rate responses to the high-intensity stimuli (70–90dB). Submitting rats to the restraint stress significantly elevated the mean respiratory rate (+72 ± 8 cpm) and the dominant respiratory rate (+1 ± 12 cpm), as well as the fraction of high-frequency respiratory rate (+10 ± 3%). Inhibition of the amygdala by muscimol significantly suppressed these responses. We conclude that the amygdala is one of the key structures that are essential for expression of respiratory responses to stressful or alerting stimuli in rats.]]> Tue 31 Jul 2018 15:18:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13287 Sat 24 Mar 2018 08:16:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18932 Sat 24 Mar 2018 07:58:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27703 Sat 24 Mar 2018 07:40:10 AEDT ]]>